The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
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AbstractBananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC50 values in the range 0.5-3 mu M. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC50 of less than 10 mu M and a CC50 of over 300 mu M. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.
All Author(s) ListTanner JA, Zheng BJ, Zhou J, Watt RM, Jiang JQ, Wong KL, Lin YP, Lu LY, He ML, Kung HF, Kesel AJ, Huang JD
Journal nameCell Chemistry Biology
Year2005
Month3
Day1
Volume Number12
Issue Number3
PublisherCELL PRESS
Pages303 - 311
ISSN1074-5521
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY

Last updated on 2020-24-10 at 02:09