A pilot study of associated factors of weight changes in community-dwelling patients with Alzheimer's disease
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摘要The objective of this investigation was to identify associated factors for weight changes in Alzheimer's disease (AD) patients. The prospective study was conducted on 20 early AD, 25 late AD psychogeriatric outpatients all over 60 years of age with family caregiver(s), and 36 normal older people as control subjects. Body anthropometry was assessed in subjects including bioelectric impedance analysis and indirect calorimetry. Total daily energy expenditure (TDEE) was estimated by questionnaire. Three-day food records and neuropsychiatric inventory were recorded. Fasting blood was analyzed for plasma tumor necrosis factor (TNF). All subjects were weighed again 6 months later. In this study the AD subjects were thinner, less physically active, but had greater caloric and protein intakes than the control subjects. The percentage weight change in the AD subjects correlated inversely with TDEE, body mass index, and plasma TNF concentration (Pearson correlation coefficient -0.40, -0.43, Spearman correlation coefficient -0.31, respectively). in conclusion, physically active AD subjects are at risk of weight loss and plasma TNF may play a role in this condition. (c) 2005 Elsevier Inc. All rights reserved.
著者Kwan M, Kwok T, Lam L, Woo J, Chiu H
期刊名稱Nutrition Research
出版年份2005
月份2
日期1
卷號25
期次2
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次111 - 118
國際標準期刊號0271-5317
語言英式英語
關鍵詞Alzheimer's disease; cytokines; dementia; nutritional status; weight loss
Web of Science 學科類別Nutrition & Dietetics; NUTRITION & DIETETICS

上次更新時間 2020-20-05 於 03:01