The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease
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摘要The importance of the role of inflammation has been suggested in the pathogenesis of Alzheimer's disease (AD). Interleukin-10 (IL-10) is an anti-inflammatory cytokine that may modulate the progression of the disease through the inhibition of the action of pro-inflammatory cytokines. In this study, three polymorphisms in the regulatory region of the IL-10 gene (-1082, -819 and -592) in 95 Chinese AD patients and 117 age-matched healthy Chinese subjects were investigated. We found that among the Chinese population, the A and C alleles at the -592 position are strongly linked to the T and C alleles at the -819 position, respectively. A strong association with AD was found for these two IL-10 polymorphisms, which are in complete linkage disequilibilum (-592C and -819C), and the odds ratio of AD is 4.03 (95% CI 1.23-13.23; p=0.011). The functional significance of the IL-10 genotype was further supported by the significant association between plasma IL-10 concentrations and genotypes that were found in an independent sample of 160 healthy male volunteers. No interaction effect between the ApoE and IL-10 genotypes is found. Therefore, we concluded that the functional polymorphisms of the IL-10 gene act as a risk factor for AD. (c) 2004 Elsevier Inc. All rights reserved.
著者Ma SL, Tang NLS, Lam LCW, Chiu HFK
期刊名稱Neurobiology of Aging
出版年份2005
月份7
日期1
卷號26
期次7
出版社ELSEVIER SCIENCE INC
頁次1005 - 1010
國際標準期刊號0197-4580
電子國際標準期刊號1558-1497
語言英式英語
關鍵詞Alzheimer's disease; IL-10; inflammation; polymorphism
Web of Science 學科類別Geriatrics & Gerontology; GERIATRICS & GERONTOLOGY; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

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