Recent advances in fetal nucleic acids in maternal plasma
Publication in refereed journal

香港中文大學研究人員

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摘要The discovery of cell-free fetal DNA in maternal plasma in 1997 has opened up new possibilities for noninvasive prenatal diagnosis. Circulating fetal DNA molecules have been detected in maternal plasma from the first trimester onwards and can be robustly detected using a variety of molecular methods. This approach has been used for the prenatal investigation of sex-linked diseases, fetal RhD status, and prenatal exclusion of beta-thalassemia major. Recently, fetal RNA has also been found in maternal plasma. Such fetal RNA has been shown to originate from the placenta and to be remarkably stable. The use of microarray-based approaches has made it feasible to rapidly generate new circulating RNA markers. It is hoped that further developments in this field will make the routine and widespread practice of noninvasive nucleic acid-based prenatal diagnosis for common pregnancy-associated disorders feasible in the near future.
著者Lo YMD
會議名稱14th Workshop on Fetal Cells and Fetal DNA
會議開始日17.04.2004
會議完結日18.04.2004
會議地點Jena
期刊名稱Journal of Histochemistry and Cytochemistry
出版年份2005
月份3
日期1
卷號53
期次3
出版社SAGE PUBLICATIONS LTD
頁次293 - 296
國際標準期刊號0022-1554
電子國際標準期刊號1551-5044
語言英式英語
關鍵詞noninvasive prenatal diagnosis; plasma DNA; plasma RNA
Web of Science 學科類別Cell Biology; CELL BIOLOGY

上次更新時間 2020-04-08 於 05:38