Cell death induced by Pteris semipinnata L. is associated with p53 and oxidant stress in gastric cancer cells
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摘要In this study, we demonstrated that Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) had stronger cytotoxicity against MKN-45, a gastric cancer cell line bearing wild-type p53 than MKN-28, another gastric cancer cell line containing missense mutation in p53. The rapid increase of ROS level was involved in the mechanism of cytotoxicity. Classical features of apoptosis induced by 5F were observed in MKN-45 cells only or more significant in MKN-45 cells than MKN-28 cells. Translocation of Bax from cytosol to mitochondria, reduction of Deltapsim and DNA fragmentation were induced by 5F in the p53-dependent manner. We conclude that the expression of Bax and its downstream molecules requires the presentation of a wild-type p53 in the cells treated by 5F. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
著者Liu ZM, Ng EKW, Liang NC, Deng YF, Leung BCS, Chen GG
期刊名稱FEBS Letters
出版年份2005
月份2
日期28
卷號579
期次6
出版社ELSEVIER SCIENCE BV
頁次1477 - 1487
國際標準期刊號0014-5793
電子國際標準期刊號1873-3468
語言英式英語
關鍵詞apoptosis; cytotoxicity; gastric cancer; glutathione; p53; Pteris semipinnata L.
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

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