Pharmacokinetic advantages of two-hour post-dose cyclosporin A level for the therapeutic drug monitoring in stable Chinese kidney transplant recipients
Publication in refereed journal


摘要Background: Recent studies in Caucasian patients show that 2-hour post-dose cyclosporin A level (C2) monitoring has excellent correlation with the actual drug exposure and risk of rejection. However, the reliability of using C2 in stable Chinese renal transplant patients is unknown. Methods: Forty-nine stable Chinese renal transplant patients receiving microemulsion cyclosporin A (Neoral(R)) as part of their immunosuppressive therapy were recruited. Area under the time-concentration curve (AUC) was determined from whole blood cyclosporin A level taken at 0, 1, 2, 4 and 6 h post-dose at time 0 month. Cyclosporin A levels were repeated at 0, 1 and 2 h post-dose at 1 and 2 months later to determine the intra-individual variation at these specific time points. Results: The average duration of transplantation was 77 8 42 months, with average daily cyclosporin dosage of 200 8 43 mg in two divided doses. AUC has excellent correlations with cyclosporin A level at 1 h (C1) and 2 h ( C2) ( r = 0.81 and 0.82 respectively, p < 0.001 for both). The correlation between AUC and trough cyclosporin A level (C0) was statistically significant but only modest ( r = 0.52, p < 0.001). On the other hand, the intra-individual coefcient of variation (CVw) of C1 was significantly larger than that of C2 (34.4 +/- 24.2 vs. 15.9 +/- 8.3%, p < 0.0001). Conclusion: We conclude that C2 level has favorable pharmacokinetic properties for therapeutic drug monitoring in stable Chinese transplant recipients. Both C1 and C2 have excellent correlation with AUC, but the intraindividual variability of C2 is much lower than that of C1. Copyright (C) 2005 S. Karger AG, Basel.
著者Leung CB, Szeto CC, Ho CS, Law WK, Lam CWK, Li PKT
期刊名稱Nephron Clinical Practice
頁次C68 - C72
關鍵詞cyclosporin; cyclosporin A pharmacokinetic study; cyclosporin A, area under the time-concentration curve
Web of Science 學科類別Urology & Nephrology; UROLOGY & NEPHROLOGY

上次更新時間 2020-04-08 於 05:36