RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese children
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摘要G-401 A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children. We studied whether gain-of-function mutations in RANTES gene were associated with asthma and atopy-related traits in Chinese children. Plasma total and aeroallergen-specific IgE concentrations were measured using micro-particte immunoassay and fluorescent enzyme immunoassay, respectively. Restriction fragment length polymorphism was used to genotype RANTES G-401A and C-28G. One hundred and twenty-nine asthmatic children and 66 controls were recruited. Their mean logarithmic plasma total IgE concentrations were 2.53 and 1.98, respectively (P<0.0001). RANTES G-401A was not associated with physician-diagnosed asthma (P = 0.408). However, RANTES -401A allele was significantly associated with IgE sensitization to cat (odds ratio 2.35; 95% Cl 1.154.77; P = 0.010). Those homozygous for -401A had higher plasma cat-specific IgE levels (P = 0.034). Subjects having -401 A were also more likely to have mold-specific IgE (odds ratio 3.82; 95% CI 1.24-12.14; P = 0.007). On spirometry, those with -401A/ A had lower forced expiratory volume in 1-s (FEV1; P = 0.044). RANTES C-28G was not associated with any outcome in this study. In conclusion, the gain-of-function mutation at -401 of RANTES promoter is associated with sensitization to cat and mold allergens and FEV1, in Chinese children. (C) 2004 Elsevier Ltd. All rights reserved.
著者Leung TF, Tang NLS, Lam CWK, Li AM, Fung SLM, Chan IHS, Wong GWK
期刊名稱Respiratory Medicine
出版年份2005
月份2
日期1
卷號99
期次2
出版社W B SAUNDERS CO LTD
頁次216 - 219
國際標準期刊號0954-6111
電子國際標準期刊號1532-3064
語言英式英語
關鍵詞asthma; atopy; polymorphism; regulated on activation, normal T cell expressed and secreted; spirometry
Web of Science 學科類別Cardiac & Cardiovascular Systems; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiovascular System & Cardiology; Respiratory System; RESPIRATORY SYSTEM

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