Action of ondansetron and CP-99,994 to modify behavior and antagonize cisplatin-induced emesis in the ferret
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AbstractThe action of ondansetron (1 mg/kg, i.p.) and (+)-(2S, 3S)-3 -(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994; 10 mg/kg, i.p.) on spontaneous behavior and the emesis induced by cisplatin (10 mg/kg, i.p.) was studied in the ferret. Ondansetron was inactive to modify behavior, but CP-99,994 reduced spontaneous locomotor activity and lip licking by 48% (P < 0.01) and 79% (P < 0.01), respectively,- CP99,994 also abolished spontaneous burrowing activity (P < 0.05). Treatment of animals with cisplatin induced an emetic response that was abolished by both ondansetron and CP-99,994 (P < 0.01). However, cisplatin did not significantly modify other behavioral measures although animals that received CP-99,994, cisplatin, or CP-99,994 in combination with cisplatin exhibited more episodes of defecation than animals that received ondansetron (P < 0.05). The action of CP-99,994 to modify behavior in this species is discussed in relation to animal models of nausea. (C) 2004 Elsevier B.V. All rights reserved.
All Author(s) ListLau AHY, Kan KKW, Lai HW, Ngan MP, Rudd JA, Wai MK, Yew DTW
Journal nameEuropean Journal of Pharmacology
Volume Number506
Issue Number3
Pages241 - 247
LanguagesEnglish-United Kingdom
Keywords5-HT3 receptor; anti-emetic; cisplatin; emesis; nausea; tachykinin NK1 receptor
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-31-05 at 02:17