Increased c-kit (CD117) expression in malignant mammary phyllodes tumors
Publication in refereed journal

香港中文大學研究人員

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摘要Mammary phyllodes tumors are uncommon stromal neoplasms, and are divided into benign, borderline and malignant groups basing on histologic criteria. While benign phyllodes tumors may recur, borderline phyllodes tumors show higher propensity to recur locally and rarely metastasize, and malignant phyllodes tumors show even higher chances of local recurrences or distant metastases. c-kit is a proto-oncogene that encodes a tyrosine kinase receptor (CD117) and is a marker for gastrointestinal stromal tumors (GIST). With the advent of therapeutic agent targeted at this receptor for GIST, we investigated 179 phyllodes tumors (101 benign, 50 borderline, 28 malignant) for c-kit expression using immunohistochemistry. The staining was compared to the degree of malignancy, and to the degree of stromal cellularity, mitotic activity, nuclear pleomorphism and stromal overgrowth. The overall positive rate for c-kit was 29% (52/179) and 17% (17/101), 24% (12/50) and 46% (13/28), respectively, for benign, borderline malignant and frank malignant phyllodes and the differences between all categories were significant (chi(2) = 13.844, P=0.001). In mammary phyllodes tumors, there was increasing c-kit expression with increasing degree of malignancy, up to 46% in malignant cases. This provides strong evidence that c-kit receptor mediated tyrosine kinase involvement in the pathogenesis of phyllodes tumors, and the therapeutic agent, ST1571, Glivec, may be a potentially useful drug for its management.
著者Tse GMK, Putti TC, Lui PCW, Loh AWI, Scolyer RA, Law BKB, Karim R, Lee CS
期刊名稱Modern Pathology
出版年份2004
月份7
日期1
卷號17
期次7
出版社NATURE PUBLISHING GROUP
頁次827 - 831
國際標準期刊號0893-3952
電子國際標準期刊號1530-0285
語言英式英語
關鍵詞breast; c-kit; CD117; immunohistochemistry; phyllodes tumor
Web of Science 學科類別Pathology; PATHOLOGY

上次更新時間 2020-14-09 於 01:57