The biology and diagnostic applications of plasma RNA
Publication in refereed journal


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摘要The detection of cell-free RNA in the plasma and serum of human subjects has opened up new investigational opportunities. Tumor-derived RNA was detected in the plasma and serum of patients with various forms of cancer. Through the development of robust extraction and quantification protocols for circulating RNA, new information regarding its biology and characteristics has been obtained. Plasma RNA was shown to be particle associated and to be surprisingly stable. Recently, fetal RNA was also demonstrated in maternal plasma. The placenta was shown to be an important source of such circulating fetal RNA. This discovery has created new prenatal diagnostic and monitoring possibilities. It is expected that circulating RNA will find application in many other clinical scenarios, including emergency medicine.
著者Lo YMD, Chiu RWK
會議名稱3rd International Symposium on Circulating Nucleic Acids in Plasma/Serum (CNAPS III) and Serum Proteomics
會議開始日09.11.2003
會議完結日12.11.2003
會議地點Santa Monica
期刊名稱Annals of the New York Academy of Sciences
出版年份2004
月份1
日期1
卷號1022
出版社NEW YORK ACAD SCIENCES
頁次135 - 139
國際標準書號1-57331-551-6
國際標準期刊號0077-8923
電子國際標準期刊號1749-6632
語言英式英語
關鍵詞circulating RNA; plasma RNA; prenatal diagnosis
Web of Science 學科類別Biochemistry & Molecular Biology; Medical Laboratory Technology; Medicine, Research & Experimental; Multidisciplinary Sciences; Oncology; Research & Experimental Medicine; Science & Technology - Other Topics

上次更新時間 2021-02-05 於 01:31