Diagnostic and epidemiological implications of regional differences in serum concentrations of proteins observed in six Asian cities
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AbstractThe IFCC Committee on Plasma Proteins has been investigating regional differences for commonly assayed plasma proteins to determine whether universal reference intervals can be applied. As a part of this study, we launched an Asian project analyzing the concentrations of 13 serum proteins whose values are standardized to CRM470, and five newer analytes: retinolbinding protein (RBP), cystatin C (CysC), light-chain-kappa (L-kappa), and light-chain-lambda (L-lambda). In Tokyo, Seoul, Kuala Lumpur, Hong Kong, Taipei and Shanghai, serum samples were collected from 146 to 415 apparently healthy individuals with nearly equal gender ratios. All assays were performed in Tokyo on a Behring Nephelometer II (BN II). Seven chemical analytes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (gammaGT), creatinine, total cholesterol (TC), triglycerides (TG) and highdensity lipoprotein cholesterol (HDLC)) were also measured. These results were used for excluding individuals with possible latent clinical disorders.
All Author(s) ListIchihara K, Itoh Y, Min WK, Yap SF, Lam CWK, Kong XT, Chou CT, Nakamura H
Journal nameClinical Chemistry and Laboratory Medicine
Volume Number42
Issue Number7
Pages800 - 809
LanguagesEnglish-United Kingdom
KeywordsCRM470; gender-related changes; multiple regression analysis; National Committee for Clinical Laboratory Standards (NCCLS); nephelometry; nested analysis of variance; reference interval
Web of Science Subject CategoriesMedical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY

Last updated on 2020-24-10 at 00:58