Development and application of a rapid diagnostic method for invasive candidiasis by the detection of D-/L-arabinitol using gas chromatography/mass spectrometry
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摘要A rapid non-culture-based diagnostic method utilizing D-/L-arabinitol (DA/LA) ratios as a chemical marker of invasive candidiasis was developed and explored. The enantiomers-ratios detection was made possible by the use of gas chromatography coupled with mass spectrometry (GC/MS). The mean DA/LA ratios +/- standard deviation (range) in urine (n = 40) and serum (n = 20) were 2.08 +/- 0.78 (0.57 to 3.55) and 1.79 +/- 0.75 (0.74 to 3.54), respectively, from patients without evidence of fungal infection or colonization; in patients (n = 7) with culture-proven invasive candida infections, the figures were 9.91 +/- 3.04 (7.24 to 16.27) and 13.58 +/- 7.31 (5.57 to 25.88) in urine and serum, respectively. The differences in DA/LA ratios between the candidemic patients and the non-candidemic patients were statistically significant (p < 0.01) in both serum and urine samples. The DA/LA ratios were not significantly affected in patients with oral or vaginal candidiasis and candiduria. (C) 2004 Elsevier Inc. All rights reserved.
著者Hui M, Cheung SW, Chin ML, Chu KC, Chan RCY, Cheng AFB
會議名稱10th Meeting of the European-Society-of-Chemotherapy-Infectious-Diseases
會議開始日28.06.2003
會議完結日01.07.2003
會議地點Vienna
期刊名稱Diagnostic Microbiology and Infectious Disease
出版年份2004
月份6
日期1
卷號49
期次2
出版社ELSEVIER SCIENCE INC
頁次117 - 123
國際標準期刊號0732-8893
語言英式英語
Web of Science 學科類別Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY

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