Development and application of a rapid diagnostic method for invasive candidiasis by the detection of D-/L-arabinitol using gas chromatography/mass spectrometry
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AbstractA rapid non-culture-based diagnostic method utilizing D-/L-arabinitol (DA/LA) ratios as a chemical marker of invasive candidiasis was developed and explored. The enantiomers-ratios detection was made possible by the use of gas chromatography coupled with mass spectrometry (GC/MS). The mean DA/LA ratios +/- standard deviation (range) in urine (n = 40) and serum (n = 20) were 2.08 +/- 0.78 (0.57 to 3.55) and 1.79 +/- 0.75 (0.74 to 3.54), respectively, from patients without evidence of fungal infection or colonization; in patients (n = 7) with culture-proven invasive candida infections, the figures were 9.91 +/- 3.04 (7.24 to 16.27) and 13.58 +/- 7.31 (5.57 to 25.88) in urine and serum, respectively. The differences in DA/LA ratios between the candidemic patients and the non-candidemic patients were statistically significant (p < 0.01) in both serum and urine samples. The DA/LA ratios were not significantly affected in patients with oral or vaginal candidiasis and candiduria. (C) 2004 Elsevier Inc. All rights reserved.
All Author(s) ListHui M, Cheung SW, Chin ML, Chu KC, Chan RCY, Cheng AFB
Name of Conference10th Meeting of the European-Society-of-Chemotherapy-Infectious-Diseases
Start Date of Conference28/06/2003
End Date of Conference01/07/2003
Place of ConferenceVienna
Journal nameDiagnostic Microbiology and Infectious Disease
Volume Number49
Issue Number2
Pages117 - 123
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesInfectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY

Last updated on 2021-21-09 at 00:19