Prophylactic phenylephrine infusion for preventing hypotension during spinal anesthesia for cesarean delivery
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摘要In a randomized, double-blinded, controlled trial, we investigated the prophylactic infusion of IV phenylephrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Immediately after intrathecal injection, phenylephrine was infused at 100 mug/min (n = 26) for 3 min. From that point until delivery, phenylephrine was infused at 100 mug/min whenever systolic arterial blood pressure (SAP), measured each minute, was less than baseline. A control group (n = 24) received IV bolus phenylephrine 100 mug after each measurement of SAP <80% of baseline. Phenylephrine infusion decreased the incidence (6 [23%] of 26 versus 21 [88%] of 24; P < 0.0001), frequency, and magnitude (median minimum SAP, 106 mm Hg; interquartile range, 95-111 mm Hg; versus median, 80 mm Hg; range, 73-93 mm Hg; P < 0.0001) of hypotension compared with control. Heart rate was significantly slower over time in the infusion group compared with the control group (P < 0.0001). Despite a large total dose of phenylephrine administered to the infusion group compared with the control group (median, 1260 mug; interquartile range, 1010-1640 mug; versus median, 450 mug; interquartile range, 300-750 mug; P < 0.0001), umbilical cord blood gases and Apgar scores were similar. One patient in each group had umbilical arterial pH <7.2. Prophylactic phenylephrine infusion is a simple, safe, and effective method of maintaining arterial blood pressure during spinal anesthesia for cesarean delivery.
著者Kee WDN, Khaw KS, Ng FF, Lee BB
會議名稱Annual Meeting of the American-Society-of-Anesthesiologists
會議開始日11.10.2003
會議完結日15.10.2003
會議地點SAN FRANCISCO
期刊名稱Anesthesia and Analgesia
出版年份2004
月份3
日期1
卷號98
期次3
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次815 - 821
國際標準期刊號0003-2999
電子國際標準期刊號1526-7598
語言英式英語
Web of Science 學科類別Anesthesiology; ANESTHESIOLOGY

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