Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases
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AbstractSevere acute respiratory syndrome (SARS) is a new human infectious disease with significant morbidity and mortality. The disease has been shown to be associated with a new coronavirus (SARS-CoV). The clinical and epidemiological aspects of SARS have been described. Moreover, the viral genome of SARS-CoV has been fully sequenced. However, much of the biological behaviour of the virus is not known and data on the tissue and cellular tropism of SARS-CoV are limited. In this study, six fatal cases of SARS were investigated for the tissue and cellular tropism of SARS-CoV using an in-situ hybridization (ISH) technique. Among all the tissues studied, positive signals were seen in pneumocytes in the lungs and surface enterocytes in the small bowel. Infected pneumocytes were further confirmed by immunofluorescence-fluorescence in-situ hybridization (FISH) analysis. These results provide important information concerning the tissue tropism of SARS-CoV, which is distinct from previously identified human coronaviruses, and suggest the possible involvement of novel receptors in this infection. Whereas the lung pathology was dominated by diffuse alveolar damage, the gut was relatively intact. These findings indicated that tissue responses to SARS-CoV infection are distinct in different organs. Copyright (C) 2004 John Wiley Sons, Ltd.
All Author(s) ListTo K, Tong JHM, Chan PKS, Au FWL, Chim SSC, Chan KCA, Cheung JLK, Liu EYM, Tse GMK, Lo AWI, Lo YMD, Ng HK
Journal nameJournal of Pathology
Volume Number202
Issue Number2
Pages157 - 163
LanguagesEnglish-United Kingdom
Keywordscoronavirus; severe acute respiratory syndrome (SARS); viral tropism
Web of Science Subject CategoriesOncology; ONCOLOGY; Pathology; PATHOLOGY

Last updated on 2020-03-08 at 03:44