Association between tumor necrosis factor-alpha promoter polymorphism and Alzheimer's disease
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AbstractTumor necrosis factor-alpha (TNFalpha) gene polymorphisms have been reported to be associated with Alzheimer's disease (AD) in Caucasian populations. Three TNFalpha polymorphisms (-857, -863, and -1,031) were studied in a Chinese population. A high-risk TNFalpha haplotype (-1,031C-863C-857C) with an odds ratio of 2.54 (95% CI 1.37 to 4.79) for AD was identified. No interaction effect of APOE and TNFalpha genotypes was found, but both acted as important risk factors for AD.
All Author(s) ListMa SL, Tang NLS, Lam LCW, Chiu HFK
Journal nameNeurology
Year2004
Month1
Day27
Volume Number62
Issue Number2
PublisherLIPPINCOTT WILLIAMS & WILKINS
Pages307 - 309
ISSN0028-3878
eISSN1526-632X
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesClinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology

Last updated on 2020-13-09 at 00:42