Early pituitary-adrenal responses and retinopathy of prematurity in very low birth weight infants
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摘要This longitudinal prospective study aimed to investigate the relationship between pituitary-adrenal responses and severity of retinopathy of prematurity (ROP) in 92 preterm, very low birth weight infants less than or equal to 30 wk gestation. The human corticotropin releasing hormone stimulation test was performed on these infants at D 7 and 14 of postnatal life. Univariate analysis revealed significant associations between severity of ROP and gestational age (r = -0.53, p < 0.0001), birth weight (r = -0.56, p < 0.0001), Apgar score at 1 min (r = -0.27, p < 0.05), Clinical Risk Index for Babies score (r = 0.48, p < 0.0001), duration of mechanical ventilation (r = 0.48, p < 0.0001), oxygen dependency (r = 0.48, p < 0.0001), and length of hospitalization (r = 0.49, p < 0.0001). The stage of ROP was also significantly associated with the basal and peak plasma ACTH (r > -0.22, p < 0.05) and peak serum cortisol (r = -0.21, p = 0.05) at d 7. Multivariate analysis using the classification and regression trees indicated that the two most influential risk factors affecting the development of advanced stages of ROP ( greater than or equal to stage 3) were i) birth weight and ii) oxygen dependency at 28 d of life or at 36 wk postconceptional age. Our findings suggest that early endogenous or stimulated pituitary-adrenal responses are not independent risk factors associated with the development of severe ROP. Low birth weight and prolonged oxygen exposure are likely to be important factors that influence the degree of damage inflicted on the retina.
著者Ng PC, Kwok AKH, Lee CH, Tam BSM, Lam CWK, Ma KC, Chan IHS, Wong E, Lam DSC, Fok TF
期刊名稱Pediatric Research
出版年份2004
月份1
日期1
卷號55
期次1
出版社INT PEDIATRIC RESEARCH FOUNDATION, INC
頁次114 - 119
國際標準期刊號0031-3998
語言英式英語
Web of Science 學科類別Pediatrics; PEDIATRICS

上次更新時間 2020-29-11 於 01:32