Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
Publication in refereed journal


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摘要Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
著者Chim SSC, Tsui SKW, Chan KCA, Au TCC, Hung ECW, Tong YK, Chiu RWK, Ng EKO, Chan PKS, Chu CM, Sung JJY, Tam JS, Fung KP, Waye MMY, Lee CY, Yuen KY, Lo YMD
期刊名稱Lancet
出版年份2003
月份11
日期29
卷號362
期次9398
出版社LANCET LTD
頁次1807 - 1808
國際標準期刊號0140-6736
電子國際標準期刊號1474-547X
語言英式英語
Web of Science 學科類別General & Internal Medicine; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL

上次更新時間 2020-29-07 於 02:21