Relative anterior spinal overgrowth in adolescent idiopathic scoliosis - Results of disproportionate endochondral-membranous bone growth
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摘要We undertook a comparative study of magnetic resonance imaging (MRI) vertebral morphometry of thoracic vertebrae of girls with adolescent idiopathic thoracic scoliosis (AIS) and age and gender-matched normal subjects, in order to investigate abnormal differential growth of the anterior and posterior elements of the thoracic vertebrae in patients with scoliosis. Previous studies have suggested that disproportionate growth of the anterior and posterior columns may contribute to the development of AIS. Whole spine MRI was undertaken on 83 girls with AIS between the age of 12 and 14 years, and Cobb's angles of between 20degrees and 90degrees and 22 age-matched controls. Multiple measurements of each thoracic vertebra were obtained from the best sagittal and axial MRI cuts. Compared with the controls, the scoliotic spines had longer vertebral bodies between T1 and T12 in the anterior column and shorter pedicles with a larger interpedicular distance in the posterior column. The differential growth between the anterior and the posterior elements of each thoracic vertebra in the patients with AIS was significantly different from that in the controls (p < 0.01). There was also a significant positive correlation between the scoliosis severity score and the ratio of differential growth between the anterior and posterior columns for each thoracic vertebra (p < 0.01). Compared with age-matched controls, the longitudinal growth of the vertebral bodies in patients with AIS is disproportionate and faster and mainly occurs by endochondral ossification. In contrast, the circumferential growth by membranous ossification is slower in both the vertebral bodies and pedicles.
著者Guo X, Chau WW, Chan YL, Cheng JCY
期刊名稱Journal of Bone and Joint Surgery, British Volume
出版年份2003
月份9
日期1
卷號85B
期次7
出版社BRITISH EDITORIAL SOC BONE JOINT SURGERY
頁次1026 - 1031
國際標準期刊號0301-620X
電子國際標準期刊號2044-5377
語言英式英語
Web of Science 學科類別Orthopedics; ORTHOPEDICS; Surgery; SURGERY

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