Human metapneumovirus detection in patients with severe acute respiratory syndrome
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摘要We used a combination approach of conventional virus isolation and molecular techniques to detect human metapneumovirus (HMPV) in patients with severe acute respiratory syndrome (SARS). Of the 48 study patients, 25 (52.1%) were infected with HMPV; 6 of these 25 patients were also infected with coronavirus, and another 5 patients (10.4%) were infected with coronavirus alone. Using this combination approach, we found that human laryngeal carcinoma (HEp-2) cells were superior to rhesus monkey kidney (LLC-MK2) cells commonly used in previous studies for isolation of HMPV. These widely available HEp-2 cells should be included in conjunction with a molecular method for cell culture followup to detect HMPV, particularly in patients with SARS.
著者Chan PKS, Tam JS, Lam CW, Chan E, Wu A, Li CK, Buckley TA, Ng KC, Joynt GM, Cheng FWT, To KF, Lee N, Hui DSC, Cheung JLK, Chu I, Liu E, Chung SCA, Sung JJY
期刊名稱Emerging Infectious Disease
出版年份2003
月份9
日期1
卷號9
期次9
出版社CENTER DISEASE CONTROL
頁次1058 - 1063
國際標準期刊號1080-6040
電子國際標準期刊號1080-6059
語言英式英語
Web of Science 學科類別Immunology; IMMUNOLOGY; Infectious Diseases; INFECTIOUS DISEASES

上次更新時間 2021-12-01 於 00:33