Generation of the Probabilistic Template of Default Mode Network Derived from Resting-State fMRI
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摘要Default-mode network (DMN) has become a prominent network among all large-scale brain networks which can be derived from the resting-state fMRI (rs-fMRI) data. Statistical template labeling the common location of hubs in DMN is favorable in the identification of DMN from tens of components resulted from the independent component analysis (ICA). This paper proposed a novel iterative framework to generate a probabilistic DMN template from a coherent group of 40 healthy subjects. An initial template was visually selected from the independent components derived from group ICA analysis of the concatenated rs-fMRI data of all subjects. An effective similarity measure was designed to choose the best-fit component from all independent components of each subject computed given different component numbers. The selected DMN components for all subjects were averaged to generate an updated DMN template and then used to select the DMN for each subject in the next iteration. This process iterated until the convergence was reached, i.e., the overlapping region between the DMN areas of the current template and the one generated from the previous stage is more than 95%. By validating the constructed DMN template on the rs-fMRI data from another 40 subjects, the generated probabilistic DMN template and the proposed similarity matching mechanism were demonstrated to be effective in automatic selection of independent components from the ICA analysis results.
著者Wang DF, Kong YY, Chu WCW, Tam CWC, Lam LCW, Wang YL, Northoff G, Mok VCT, Wang YJ, Shi L
期刊名稱IEEE Transactions on Biomedical Engineering
出版年份2014
月份10
日期1
卷號61
期次10
出版社IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
頁次2550 - 2555
國際標準期刊號0018-9294
電子國際標準期刊號1558-2531
語言英式英語
關鍵詞Brain network; default mode network (DMN); resting-state fMRI (rs-fMRI); template
Web of Science 學科類別Engineering; Engineering, Biomedical

上次更新時間 2020-13-10 於 01:11