Computational Morphometry of Semicircular Canals in Adolescent Idiopathic Scoliosis (AIS) Based on High-Resolution MR Images
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摘要Introduction: Different subclinical neurological dysfunction has been reported in AIS, including poor postural control and asymmetric otolith vestibulo-ocular responses compared with normal controls.

Objectives: The objective of this study is to establish whether abnormal MRI morphoanatomical changes arise in vestibular system (VS) in AIS when compared with controls using computational morphometry techniques.

Materials and methods: High resolution T2W images of VS of 19 right-thoracic AIS and 12 age-matched controls were acquired. A best-fit plane and a best-fit circle were calculated to approximate each semicircular canal. The shape of VS was measured by the length and angle formed by the lines connecting the centres of each pair of best-fit circles, the radius of the circles, and the rotational angles and compared the rotational angles around three axes of coordinate system. Statistical analysis was done with one-way ANOVA.

Results: Significant difference in the shape of left-side semicircular canals between AIS and controls: (1) distance between the centers of the lateral and superior canals (p=0.007) (AISNC). No significance group difference was found in right-side VS. (4) Orientation asymmetry between left-side and right-side VS along z axis (p=0.0067) (AIS>NC).

Conclusion and significance: These morphological changes are likely to be related to subclinical postural, vestibular, and proprioceptive dysfunctions. Further association studies and longitudinal studies could help to further define the link between morphological and functional dysfunction, which might have important predictive and prognostic effect on curve development and progression.
著者Chu WCW, Shi L, Wang D, Cheng JCY
會議名稱9th Biennial Meeting of the International-Research-Society-of-Spinal-Deformities (IRSSD)
會議開始日01.07.2012
會議完結日04.07.2012
會議地點Poznan
會議國家/地區波蘭
期刊名稱Studies in Health Technology and Informatics
會議論文集題名Research into Spinal Deformities
系列標題Studies in Health Technology and Informatics
叢書冊次176
出版年份2012
月份7
日期4
卷號8
出版社IOS PRESS
頁次480 - 480
國際標準書號978-1-61499-066-6
電子國際標準書號978-1-61499-067-3
國際標準期刊號0926-9630
語言英式英語
Web of Science 學科類別Orthopedics

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