Computational Morphometry of Semicircular Canals in Adolescent Idiopathic Scoliosis (AIS) Based on High-Resolution MR Images
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AbstractIntroduction: Different subclinical neurological dysfunction has been reported in AIS, including poor postural control and asymmetric otolith vestibulo-ocular responses compared with normal controls.

Objectives: The objective of this study is to establish whether abnormal MRI morphoanatomical changes arise in vestibular system (VS) in AIS when compared with controls using computational morphometry techniques.

Materials and methods: High resolution T2W images of VS of 19 right-thoracic AIS and 12 age-matched controls were acquired. A best-fit plane and a best-fit circle were calculated to approximate each semicircular canal. The shape of VS was measured by the length and angle formed by the lines connecting the centres of each pair of best-fit circles, the radius of the circles, and the rotational angles and compared the rotational angles around three axes of coordinate system. Statistical analysis was done with one-way ANOVA.

Results: Significant difference in the shape of left-side semicircular canals between AIS and controls: (1) distance between the centers of the lateral and superior canals (p=0.007) (AISNC). No significance group difference was found in right-side VS. (4) Orientation asymmetry between left-side and right-side VS along z axis (p=0.0067) (AIS>NC).

Conclusion and significance: These morphological changes are likely to be related to subclinical postural, vestibular, and proprioceptive dysfunctions. Further association studies and longitudinal studies could help to further define the link between morphological and functional dysfunction, which might have important predictive and prognostic effect on curve development and progression.
All Author(s) ListChu WCW, Shi L, Wang D, Cheng JCY
Name of Conference9th Biennial Meeting of the International-Research-Society-of-Spinal-Deformities (IRSSD)
Start Date of Conference01/07/2012
End Date of Conference04/07/2012
Place of ConferencePoznan
Country/Region of ConferencePoland
Journal nameStudies in Health Technology and Informatics
Proceedings TitleResearch into Spinal Deformities
Series TitleStudies in Health Technology and Informatics
Number in Series176
Volume Number8
PublisherIOS PRESS
Pages480 - 480
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesOrthopedics

Last updated on 2021-21-09 at 00:00