Elevated Soluble Leptin Receptor Level and Association with Body Composition in Girls with Adolescent Idiopathic Scoliosis
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AbstractIntroduction: Leptin has been postulated as one of the etiologic factors of adolescent idiopathic scoliosis (AIS) because of its functions in regulating bone and energy metabolism. Soluble leptin receptor (sOB-R) has been shown to modulate the bioavailability of leptin. It is hypothesized that AIS girls have different body composition that is associated with abnormal bioavailability of leptin and sOB-R levels.

Materials and methods: 84 AIS girls aged 12 to 14 and 71 age-matched control girls were recruited. Subjects with BMI>23.0 were excluded. Body composition including skeletal muscle mass (SMM) and body fat (BF) mass were measured with bioelectrical impedance analysis. Serum total leptin and sOB-R levels were measured with ELISA.

Results: AIS girls have lower BMI (p=0.008), free leptin index (leptin/sOB-R) (p=0.029) and higher sOB-R (p=0.001) than controls. With multiple regression analysis for the associations between sOB-R vs. percentage BF, BMI and leptin, AIS girls have significantly different slopes (p=<0.001, 0.005 and 0.001 respectively). The subjects were further sub-grouped into normal (18.5
All Author(s) ListTam EMS, Yeung HY, Liu Z, Lam TP, Ting T, Lok JYF, Ng BKW, Lee KM, Yong Q, Cheng JCY
Name of Conference9th Biennial Meeting of the International-Research-Society-of-Spinal-Deformities (IRSSD)
Start Date of Conference01/07/2012
End Date of Conference04/07/2012
Place of ConferencePoznan
Country/Region of ConferencePoland
Journal nameStudies in Health Technology and Informatics
Proceedings TitleResearch into Spinal Deformities
Series TitleStudies in Health Technology and Informatics
Number in Series176
Volume Number8
PublisherIOS PRESS
Pages472 - 472
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesOrthopedics

Last updated on 2020-18-11 at 01:08