Elevated Soluble Leptin Receptor Level and Association with Body Composition in Girls with Adolescent Idiopathic Scoliosis
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摘要Introduction: Leptin has been postulated as one of the etiologic factors of adolescent idiopathic scoliosis (AIS) because of its functions in regulating bone and energy metabolism. Soluble leptin receptor (sOB-R) has been shown to modulate the bioavailability of leptin. It is hypothesized that AIS girls have different body composition that is associated with abnormal bioavailability of leptin and sOB-R levels.

Materials and methods: 84 AIS girls aged 12 to 14 and 71 age-matched control girls were recruited. Subjects with BMI>23.0 were excluded. Body composition including skeletal muscle mass (SMM) and body fat (BF) mass were measured with bioelectrical impedance analysis. Serum total leptin and sOB-R levels were measured with ELISA.

Results: AIS girls have lower BMI (p=0.008), free leptin index (leptin/sOB-R) (p=0.029) and higher sOB-R (p=0.001) than controls. With multiple regression analysis for the associations between sOB-R vs. percentage BF, BMI and leptin, AIS girls have significantly different slopes (p=<0.001, 0.005 and 0.001 respectively). The subjects were further sub-grouped into normal (18.5
著者Tam EMS, Yeung HY, Liu Z, Lam TP, Ting T, Lok JYF, Ng BKW, Lee KM, Yong Q, Cheng JCY
會議名稱9th Biennial Meeting of the International-Research-Society-of-Spinal-Deformities (IRSSD)
會議開始日01.07.2012
會議完結日04.07.2012
會議地點Poznan
會議國家/地區波蘭
期刊名稱Studies in Health Technology and Informatics
會議論文集題名Research into Spinal Deformities
系列標題Studies in Health Technology and Informatics
叢書冊次176
出版年份2012
月份7
日期4
卷號8
出版社IOS PRESS
頁次472 - 472
國際標準書號978-1-61499-066-6
電子國際標準書號978-1-61499-067-3
國際標準期刊號0926-9630
語言英式英語
Web of Science 學科類別Orthopedics

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