ALENDRONATE REDUCED PERI-TUNNEL BONE LOSS AND ENHANCED TENDON GRAFT TO BONE TUNNEL HEALING IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
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摘要Peri-tunnel bone loss after anterior cruciate ligament (ACL) reconstruction is commonly observed, both clinically and experimentally. We aimed to study the effect and mechanisms of different doses of alendronate in the reduction of peri-tunnel bone loss and promotion of graft-bone tunnel healing in ACL reconstruction. Eighty-four ACL-reconstructed rats were divided into 4 groups. Alendronate at different dosages, or saline, were injected subcutaneously weekly, for 2 or 6 weeks post-reconstruction, for vivaCT (computed tomography) imaging, biomechanical tests, histology and immunohistochemistry. Alendronate significantly increased bone mass and density of tissue inside bone tunnels except at the epiphyseal region of tibial tunnel. The femoral tunnel diameter decreased significantly in the mid-dose and high-dose alendronate groups compared to that in the saline group at week 6. Alendronate significantly increased the peri-tunnel bone mass and density along all tunnel regions at week 6. Better graft-bone tunnel integration and intra-tunnel graft integrity were observed in the alendronate groups. The ultimate load was significantly higher in the mid-dose and high-dose alendronate groups at week 2, but not at week 6. There was a reduction in matrix metalloprotein (MMP)1, MMP13 and CD68-positive cells at the peri-tunnel region and graft-bone interface in the alendronate-treated group compared to the saline group. Alendronate reduced peri-tunnel bone resorption, increased mineralised tissue inside bone tunnel as well as histologically and biomechanically promoted graft-bone tunnel healing, probably by reducing the expression of MMP1, MMP13 and CD68-positive cells. Alendronate might be used for reducing peri-tunnel bone loss and promoting graft-bone tunnel healing at early stage post-ACL reconstruction.
著者Lui PPY, Lee YW, Mok TY, Cheuk YC, Chan KM
期刊名稱eCells and Materials Journal
出版年份2013
月份1
日期1
卷號25
出版社AO RESEARCH INSTITUTE DAVOS-ARI
頁次78 - 96
國際標準期刊號1473-2262
語言英式英語
關鍵詞alendronate; Anterior cruciate ligament reconstruction; bisphosphonate; peri-tunnel bone loss; tendon graft to bone tunnel healing
Web of Science 學科類別Cell & Tissue Engineering; CELL & TISSUE ENGINEERING; Cell Biology; Engineering; Engineering, Biomedical; ENGINEERING, BIOMEDICAL; Materials Science; Materials Science, Biomaterials; MATERIALS SCIENCE, BIOMATERIALS

上次更新時間 2021-12-09 於 00:14