The role of the Ala746Thr variant in the ATP13A2 gene among Chinese patients with Parkinson's disease
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AbstractThe association between idiopathic Parkinson's disease (PD) and the ATP13A2 (PARK9) Ala746Thr variant, associated with Kufor-Rakeb syndrome, is controversial. We investigated this association in 69 patients with early onset PD (EOPD; <= 50 years of age), 192 patients with late onset PD (LOPD; > 50 years of age), and 180 healthy controls in the Chinese population in Hong Kong. The presence of the Ala746Thr variant in the ATP13A2 locus was examined in all participants. We detected the heterozygous Ala746Thr variant in one healthy control (0.6%), one patient with EOPD (1.4%, p = 0.50), and one patient with LOPD (0.5%, p = 0.96). We suggest that the ATP13A2 Ala746Thr variant is not a common risk factor for PD in the Chinese population in Hong Kong. (C) 2012 Elsevier Ltd. All rights reserved.
All Author(s) ListChan AYY, Baum L, Tang NLS, Lau CYK, Ng PW, Hui KF, Mizuno Y, Kwan JY, Mok VCT, Kuo SH
Journal nameJournal of Clinical Neuroscience
Year2013
Month5
Day1
Volume Number20
Issue Number5
PublisherELSEVIER SCI LTD
Pages761 - 762
ISSN0967-5868
eISSN1532-2653
LanguagesEnglish-United Kingdom
KeywordsATP13A2; Chinese; Genetics; PARK9; Parkinson's disease
Web of Science Subject CategoriesClinical Neurology; CLINICAL NEUROLOGY; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

Last updated on 2020-27-10 at 01:35