Association between high serum total bilirubin and post-stroke depression
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AbstractAim High serum bilirubin predicts depression in non-stroke subjects, but it is unknown whether it also predicts post-stroke depression (PSD). This study examined the association between the risk of PSD and bilirubin level. Methods Six hundred and thirty-five patients with acute ischemic stroke in Hong Kong were recruited. Serum total bilirubin, alanine transaminase and alkaline phosphatase levels were measured in all patients during their hospital stay. A psychiatrist gave the Structured Clinical Interview for DSM-IV to all patients 3 months after the index stroke, with 61 patients diagnosed with PSD: 27 with major depression, 24 with minor depression and 10 with dysthymia. Results In the full sample, the 25%, 50% and 75% percentile bilirubin levels were 7.0, 10.0 and 14.0mol/L, respectively. Significant differences were found between the PSD and non-PSD groups in terms of bilirubin level (P=0.006). In post-hoc comparisons, the proportion of patients with bilirubin 14.1mol/L was significantly higher in the PSD group (37.7% vs 19.7%, P=0.001). In the final regression model, bilirubin level (14.1mol/L) remained a significant independent predictor of PSD, with an odds ratio of 2.4. Conclusions High bilirubin level is associated with PSD. Further investigations are needed to clarify the underlying pathophysiological link between bilirubin level and PSD.
All Author(s) ListTang WK, Liang HJ, Chu WCW, Mok V, Ungvari GS, Wong KS
Journal namePsychiatry and Clinical Neurosciences
Volume Number67
Issue Number4
Pages259 - 264
LanguagesEnglish-United Kingdom
Keywordsacute ischemic stroke; bilirubin; depression; magnetic resonance imaging; stroke
Web of Science Subject CategoriesClinical Neurology; CLINICAL NEUROLOGY; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology; Psychiatry; PSYCHIATRY, SCI

Last updated on 2021-12-09 at 00:14