Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program
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AbstractBACKGROUND: Nasopharyngeal carcinoma (NPC) is prevalent in Southeast Asia. Over the last decade, plasma Epstein-Barr virus (EBV) DNA has been developed as a tumor marker for NPC. In this study, the authors investigated whether plasma EBV DNA analysis is useful for NPC surveillance. METHODS: In total, 1318 volunteers ages 40 to 60 years were prospectively recruited. Plasma EBV DNA and serology for viral capsid antigen immunoglobulin A (IgA) were measured. Participants who had detectable plasma EBV DNA or positive IgA serology underwent nasal endoscopic examination and a follow-up plasma EBV DNA analysis in approximately 2 weeks. All participants were followed for 2 years to record the development of NPC. RESULTS: Three individuals with NPC were identified at enrolment. All of them were positive for EBV DNA and remained positive in follow-up analysis. Only 1 of those patients was positive for EBV serology. In 1 patient who had NPC with a small tumor confined to the mucosa, the tumor was not detectable on endoscopic examination. Because of a 2-fold increase in plasma EBV DNA on the follow-up analysis, that patient underwent magnetic resonance imaging, which revealed the tumor. Among the participants who did not have NPC but had initially positive plasma EBV DNA results, approximately 66% had negative EBV DNA results after a median of 2 weeks. CONCLUSIONS: Plasma EBV DNA analysis proved useful for detecting early NPC in individuals without a clinical suspicion of NPC. Repeating the test in those who had initially positive results differentiated those with NPC from those who had false-positive results. Cancer 2013. (c) 2013 American Cancer Society.
All Author(s) ListChan KCA, Hung ECW, Woo JKS, Chan PKS, Leung SF, Lai FPT, Cheng ASM, Yeung SW, Chan YW, Tsui TKC, Kwok JSS, King AD, Chan ATC, van Hasselt AC, Lo YMD
Journal nameCancer
Year2013
Month5
Day15
Volume Number119
Issue Number10
PublisherWILEY-BLACKWELL
Pages1838 - 1844
ISSN0008-543X
eISSN1097-0142
LanguagesEnglish-United Kingdom
Keywordsearly cancer detection; molecular marker; nasopharyngeal carcinoma screening; plasma Epstein-Barr virus DNA
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-29-11 at 00:56