Alns: a new searchable and filterable sequence alignment format
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AbstractNucleotides and amino acids are basic building units of RNA, DNA and protein. Although intensive studies on understanding how changes in these building blocks affect the phenotypes of these biopolymers are ever increasing, many popular alignment formats are generated by pair-wise comparison tools such as the Basic Local Alignment Search Tool (BLAST). These alignments are user-friendly to researchers but are not convenient for searching, filtering and storage, in particular when there are thousands of alignments generated from highly conserved sequences. Here, we introduce a new alignment format, alns, to facilitate rapid and convenient association of genetic changes and similarity to other sources of information such as phenotypes, disease state, time, geography and taxonomy via simple spreadsheet functions. The format shall assist biologists from a wide range of disciplines in knowledge discovery.
All Author(s) ListLeung RKK, Tsui SKW
Journal nameInternational Journal of Data Mining and Bioinformatics
Detailed descriptionTo ORKTS: DOI: 10.1504/IJDMB.2013.053193
Volume Number7
Issue Number2
Pages135 - 145
LanguagesEnglish-United Kingdom
Keywordsalns; bioinformatics; sequence alignment format
Web of Science Subject CategoriesMathematical & Computational Biology; MATHEMATICAL & COMPUTATIONAL BIOLOGY

Last updated on 2020-07-06 at 00:21