ViralFusionSeq: accurately discover viral integration events and reconstruct fusion transcripts at single-base resolution
Publication in refereed journal


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其它資訊
摘要Insertional mutagenesis from virus infection is an important pathogenic risk for the development of cancer. Despite the advent of high-throughput sequencing, discovery of viral integration sites and expressed viral fusion events are still limited. Here, we present ViralFusionSeq (VFS), which combines soft-clipping information, read-pair analysis and targeted de novo assembly to discover and annotate viral-human fusions. VFS was used in an RNA-Seq experiment, simulated DNA-Seq experiment and re-analysis of published DNA-Seq datasets. Our experiments demonstrated that VFS is both sensitive and highly accurate.
著者Li JW, Wan R, Yu CS, Co NN, Wong N, Chan TF
期刊名稱Bioinformatics
出版年份2013
月份3
日期1
卷號29
期次5
出版社OXFORD UNIV PRESS
頁次649 - 651
國際標準期刊號1367-4803
電子國際標準期刊號1460-2059
語言英式英語
Web of Science 學科類別Biochemical Research Methods; BIOCHEMICAL RESEARCH METHODS; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Computer Science; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; MATHEMATICAL & COMPUTATIONAL BIOLOGY; Mathematics; Statistics & Probability

上次更新時間 2020-04-08 於 05:03