In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
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AbstractAntiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women. However, long-termtreatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies. Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats. To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment. Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks. From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P = 0.014) and 5.94% (0.25mg/kg/day of raloxifene; P = 0.026) when compared with the respective dosage groups with raloxifene alone. Similar synergistic effects were also observed in BMD increase at distal femur (0.25mg/kg/day; P = 0.001) and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P = 0.02). However, such interactions could not be observed in all alendronate-treated groups. Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.
All Author(s) ListKo CH, Siu WS, Wong HL, Gao S, Shum WT, Lau CP, Cheng SW, Tam JCW, Hung LK, Fung KP, Lau CBS, Han QB, Leung PC
Journal nameEvidence-Based Complementary and Alternative Medicine
Detailed descriptionVolume 2012\n\nTo ORKTS: Dr. Quan-Bin Han is non-CU staff, Dr. Han is staff at School of Chinese Medicine, HK Baptist University.
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Year2012
Month1
Day1
PublisherHINDAWI PUBLISHING CORPORATION
ISSN1741-427X
eISSN1741-4288
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesIntegrative & Complementary Medicine; INTEGRATIVE & COMPLEMENTARY MEDICINE

Last updated on 2020-25-10 at 01:25