PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要Telomerase recruitment to telomere is the prerequisite for telomere extension, but the proteins involved in this process are still largely unknown. PinX1 is a telomerase inhibitor and has been implicated in telomere maintenance. Silencing of PinX1 significantly reduced the localization of telomerase to telomere during mid-late S phase, suggesting the involvement of PinX1 in the cell cycle-dependent trafficking of hTERT to telomere. We also revealed that PinX1 mediated the chromosomal localization of hTERT during anaphase. This study revealed the role of PinX1 in telomerase function regulation by mediating its localization inside cells. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
著者Cheung DHC, Kung HF, Huang JJ, Shaw PC
期刊名稱FEBS Letters
詳細描述DOI: 10.1016/j.febslet.2012.06.028.
出版年份2012
月份9
日期21
卷號586
期次19
出版社ELSEVIER SCIENCE BV
頁次3166 - 3171
國際標準期刊號0014-5793
電子國際標準期刊號1873-3468
語言英式英語
關鍵詞Cell cycle; Immunofluorescence; Mitosis; PinX1; Telomerase recruitment
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

上次更新時間 2020-26-11 於 01:06