PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization
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AbstractTelomerase recruitment to telomere is the prerequisite for telomere extension, but the proteins involved in this process are still largely unknown. PinX1 is a telomerase inhibitor and has been implicated in telomere maintenance. Silencing of PinX1 significantly reduced the localization of telomerase to telomere during mid-late S phase, suggesting the involvement of PinX1 in the cell cycle-dependent trafficking of hTERT to telomere. We also revealed that PinX1 mediated the chromosomal localization of hTERT during anaphase. This study revealed the role of PinX1 in telomerase function regulation by mediating its localization inside cells. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
All Author(s) ListCheung DHC, Kung HF, Huang JJ, Shaw PC
Journal nameFEBS Letters
Detailed descriptionDOI: 10.1016/j.febslet.2012.06.028.
Year2012
Month9
Day21
Volume Number586
Issue Number19
PublisherELSEVIER SCIENCE BV
Pages3166 - 3171
ISSN0014-5793
eISSN1873-3468
LanguagesEnglish-United Kingdom
KeywordsCell cycle; Immunofluorescence; Mitosis; PinX1; Telomerase recruitment
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

Last updated on 2020-15-10 at 01:21