Three-dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model
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摘要We aimed to establish a novel approach with 3D high frequency power Doppler ultrasonography (3D-HF-PDU) to assess microvasculature at the fracture site in rat femurs by comparing with microCT-based microangiography. Twenty-four 9-month-old ovariectomized (OVX) osteoporotic rats and age-matched sham-ovariectomized (Sham) rats were used for establishing closed fracture models on right femora. At 2, 4, and 8 weeks post-operatively, four rats in each group underwent in vivo 3D-HF-PDU scanning for evaluation of vascularization and blood flow at the fracture site. Then the fractured femora were harvested for ex vivo microangiography, and neovasculatures within the callus were reconstructed for vascular volume analysis. Correlation between the vascular volumes of the two methodologies was examined. Both 3D-HF-PDU and microangiography showed a decline of vascular volume at the fracture site from 2 to 8 weeks and a significantly larger volume in the Sham group than the OVX group. A significant linear positive correlation (r?=?0.87, p?
著者Sun MH, Leung KS, Zheng YP, Huang YP, Wang LK, Qin L, Leung AHC, Chow SKH, Cheung WH
期刊名稱Journal of Orthopaedic Research
詳細描述doi: 10.1002/jor.21490.
出版年份2012
月份1
日期1
卷號30
期次1
出版社WILEY-BLACKWELL
頁次137 - 143
國際標準期刊號0736-0266
電子國際標準期刊號1554-527X
語言英式英語
關鍵詞3D power Doppler; fracture healing; high frequency ultrasound; microCT microangiography; microvasculature
Web of Science 學科類別Orthopedics; ORTHOPEDICS

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