Anti-inflammatory activity of patchouli alcohol isolated from Pogostemonis Herba in animal models
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摘要Pogostemonis Herbs has long been used in traditional Chinese medicine for the treatment of inflammatory disorders. Patchouli alcohol (PA), a tricyclic sesquiterpene isolated from Pogostemonis Herba, is known to possess a variety of pharmacological activities. The present study aimed to investigate the in vivo anti-inflammatory effect of PA using two common inflammatory animal models i.e., xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. The degree of edema in both inflammatory animals, as well as the protein and mRNA expression of some inflammatory mediators including tumor necrosis factor-a (TNF-alpha), interleukin-1 beta(IL-1 beta), prostaglandin E(2) (PGE(2)) and nitric oxide (NO) in the hind paw of carrageenan-treated rats were measured. Results showed that PA (10-40 mg/kg) significantly inhibited the ear edema induced by xylene in mice and the paw edema induced by carrageenan in rats. In addition, treatment with PA (10-40 mg/kg) also dose-dependently decreased the production of TNF-alpha, IL-1 beta, PGE(2) and NO in the hind paw of carrageenan-treated rats. Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1 beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats. These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by clown-regulating the mRNA expression of a panel of inflammatory mediators including TNF-alpha, IL-1 beta, iNOS and COX-2. (C) 2011 Elsevier B.V. All rights reserved.
著者Li YC, Xian YF, Ip SP, Su ZR, Su JY, He JJ, Xie QF, Lai XP, Lin ZX
期刊名稱Fitoterapia
出版年份2011
月份12
日期1
卷號82
期次8
出版社ELSEVIER SCIENCE BV
頁次1295 - 1301
國際標準期刊號0367-326X
電子國際標準期刊號1873-6971
語言英式英語
關鍵詞Anti-inflammatory activity; Carrageenan; Patchouli alcohol; Pogostemonis Herbs; Xylene
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-17-11 於 23:45