MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix
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摘要Bone development is dynamically regulated by homeostasis, in which a balance between adipocytes and osteoblasts is maintained. Disruption of this differentiation balance leads to various bone-related metabolic diseases, including osteoporosis. In the present study, a primate-specific microRNA (miR-637) was found to be involved in the differentiation of human mesenchymal stem cells (hMSCs). Our preliminary data indicated that miR-637 suppressed the growth of hMSCs and induced S-phase arrest. Expression of miR-637 was increased during adipocyte differentiation (AD), whereas it was decreased during osteoblast differentiation (OS), which suggests miR-637 could act as a mediator of adipoosteogenic differentiation. Osterix (Osx), a significant transcription factor of osteoblasts, was shown to be a direct target of miR-637, which significantly enhanced AD and suppressed OS in hMSCs through direct suppression of Osx expression. Furthermore, miR-637 also significantly enhanced de novo adipogenesis in nude mice. In conclusion, our data indicated that the expression of miR-637 was indispensable for maintaining the balance of adipocytes and osteoblasts. Disruption of miR-637 expression patterns leads to irreversible damage to the balance of differentiation in bone marrow.
著者Zhang JF, Fu WM, He ML, Wang H, Wang WM, Yu SC, Bian XW, Zhou J, Lin MCM, Lu G, Poon WS, Kung HF
期刊名稱Molecular Biology of the Cell
詳細描述To ORKTS: Updated this record and delete duplication (P116828) on 24-Feb-2015.
出版年份2011
月份11
日期1
卷號22
期次21
出版社AMER SOC CELL BIOLOGY
頁次3955 - 3961
國際標準期刊號1939-4586
電子國際標準期刊號1939-4586
語言英式英語
Web of Science 學科類別Cell Biology; CELL BIOLOGY

上次更新時間 2020-29-11 於 00:52