Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy
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摘要Aim: To determine the association between polymorphisms of the multiclrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. Materials & methods: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele distributions in drug-responsive and drug-resistant patients were compared. Results: Genotype distributions of all the selected SNPs were consistent with Hardy Weinberg equilibrium. None of the polymorphisms, either genotype or allele distributions, were significantly associated with drug resistance. For each gene, no haplotypes of over 1% frequency, and that included all SNPs of the gene, were associated with drug resistance. Conclusion: This gene-wide tagging study revealed no association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy.
著者Kwan P, Wong V, Ng PW, Lui CHT, Sin NC, Wong KS, Baum L
期刊名稱Pharmacogenomics
出版年份2011
月份3
日期1
卷號12
期次3
出版社FUTURE MEDICINE LTD
頁次319 - 325
國際標準期刊號1462-2416
電子國際標準期刊號1744-8042
語言英式英語
關鍵詞ABCC2; ABCC5; ABCG2; antiepileptic drugs; drug resistance; epilepsy; pharmacogenomics
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-29-11 於 00:50