Personalized medicine for non-small-cell lung cancer
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AbstractNon-small-cell lung cancer (NSCLC) is a heterogeneous illness associated with a high mortality rate. Personalized therapy may improve treatment outcomes by identification of a specific genotypic anomaly and target-specific therapy. The most significant development in recent years was the discovery of activated EGF receptor (EGFR) mutations at exons 19 and 21. Patients with EGFR mutations respond dramatically to EGFR tyrosine kinase inhibitors such as gefitinib or erlotinib, resulting in longer progression-free survival. Multiple randomized studies, including the Iressa Pan-Asia Study and WJTOG3405, have confirmed the role of EGFR tyrosine kinase inhibitors as standard first-line therapy for patients with the EGFR mutation. In this article, we summarize the current nonpersonalized therapies and examine the available and investigational personalized therapies for patients with resectable early-stage, unresectable locally advanced, or metastatic disease.
All Author(s) ListMok TS, Zhou Q, Leung L, Loong HH
Journal nameExpert Review of Anticancer Therapy
Year2010
Month10
Day1
Volume Number10
Issue Number10
PublisherEXPERT REVIEWS
Pages1601 - 1611
ISSN1473-7140
eISSN1744-8328
LanguagesEnglish-United Kingdom
Keywordsepidermal growth factor; erlotinib; gefitinib; individualized medicine; non-small-cell lung carcinoma; receptor; receptor protein tyrosine kinases
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-26-11 at 01:02