Neuroprotective Effect of Honokiol and Magnolol, Compounds from Magnolia officinalis, on Beta-amyloid-induced Toxicity in PC12 Cells
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AbstractAmyloid beta peptide (A beta) induced toxicity is a well-established pathway of neuronal cell death which might play a role in Alzheimer's disease. In this regard, the toxic effect of A beta on a cultured A beta-sensitive neuronal cell line was used as a primary screening tool for potential anti-Alzheimer's therapeutic agents. The effects of nine pure compounds (vitamin E, alpha-asarone, salidroside, baicolin, magnolol, gastrodin, bilobalide, honokiol and beta-asarone) from selected Chinese herbs on neuronal cell death induced by A beta in NGF-differentiated PC12 cells were examined. Only two of the studied compounds, honokiol and magnolol, significantly decreased A beta-induced cell death. Further experiments indicated that their neuroprotective effects are possibly mediated through reduced ROS production as well as suppression of intracellular calcium elevation and inhibition of caspase-3 activity. The results provide for the first time a scientific rationale for the clinical use of honokiol and magnolol in the treatment of Alzheimer's disease. Copyright (c) 2010 John Wiley & Sons, Ltd.
All Author(s) ListHoi CP, Ho YP, Baum L, Chow AHL
Journal namePhytotherapy Research
Volume Number24
Issue Number10
Pages1538 - 1542
LanguagesEnglish-United Kingdom
KeywordsA beta; Alzheimer's disease; apoptosis; calcium; neuroprotective; neurotoxicity
Web of Science Subject CategoriesChemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-15-10 at 01:15