Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy
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摘要Surgery is recommended for pharmacoresistant temporal lobe epilepsy (TLE), but seizures recur in approximately one third of patients postsurgery. P-glycoprotein is an efflux multidrug transporter that is overexpressed in a range of epileptogenic pathologies. We hypothesized that increased expression of P-glycoprotein in the epileptogenic temporal lobe might be a marker for recurrence of pharmacoresistant seizures postsurgery. We performed immunohistochemistry on temporal lobe tissues resected from 69 patients who underwent anterior temporal lobectomy for pharmacoresistant TLE with histopathological proven hippocampal sclerosis. P-glycoprotein expression was rated by three pathologists independently. Patients with seizure recurrence (n = 22) had greater number of positively stained capillaries (p = 0.001) and higher P-glycoprotein immunoreactive score in capillaries (p = 0.002) in the white matter of resected temporal lobe. The differences remained significant in multivariate analysis (p = 0.002 and 0.006, respectively). The results suggest that P-glycoprotein expression in temporal lobe may be associated with seizure recurrence after surgery for pharmacoresistant TLE. (C) 2010 Elsevier Inc. All rights reserved.
著者Kwan P, Li HM, Al-Jufairi E, Abdulla R, Gonzales M, Kaye AH, Szoeke C, Ng HK, Wong KS, O'Brien TJ
期刊名稱Neurobiology of Disease
出版年份2010
月份8
日期1
卷號39
期次2
出版社ACADEMIC PRESS INC ELSEVIER SCIENCE
頁次192 - 197
國際標準期刊號0969-9961
電子國際標準期刊號1095-953X
語言英式英語
關鍵詞Epilepsy surgery; Hippocampal sclerosis; P-glycoprotein; Temporal lobectomy
Web of Science 學科類別Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

上次更新時間 2021-13-01 於 00:42