CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation
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AbstractUsing inverse polymerase chain reaction, we identified CD44, located on chromosome 11p13, as a novel translocation partner of IGH in 9 of 114 cases of gastric, nongastric extranodal, follicular, and nodal diffuse large B-cell lymphoma (DLBCL). Notably, these translocations involving IGHS mu were detected in follicular lymphomas and exclusively in germinal center B cell-like (GCB)-DLBCLs. CD44 is notexpressed in reactive GC B cells. The IGHS mu/CD44 translocations substitute S mu for the CD44 promoter and remove exon 1 of CD44, resulting in the overexpression of I mu-CD44 hybrid mRNA transcripts activated from derivative 11 that encode a new CD44 variant lacking the leader peptide and with a unique C-terminus (CD44 Delta Ex1). When overexpressed in vitro in the CD44(-) GCB-DLBCL cell line BJAB, CD44 Delta Ex1-green fluorescent protein localized to the cytoplasm and nucleus, whereas CD44s-green fluorescent protein (standard form) localized to the plasma membrane. The ectopic expression of CD44 Delta Ex1 in BJAB cells enhanced their proliferation rate and clonogenic ability, indicating a possible pathogenic role of the translocation. (Blood. 2010;115:2458-2461)
All Author(s) ListHu XT, Chen YW, Liang ACT, Au WY, Wong KY, Wan TSK, Wong MLY, Shen LJ, Chan KK, Guo TH, Chu KM, Tao Q, Chim CS, Loong F, Choi WWL, Lu LW, So CC, Chan LC, Kwong YL, Liang RHS, Srivastava G
Journal nameBlood
Year2010
Month3
Day25
Volume Number115
Issue Number12
PublisherAMER SOC HEMATOLOGY
Pages2458 - 2461
ISSN0006-4971
eISSN1528-0020
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesHematology; HEMATOLOGY

Last updated on 2020-17-11 at 01:27