CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation
Publication in refereed journal

香港中文大學研究人員

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摘要Using inverse polymerase chain reaction, we identified CD44, located on chromosome 11p13, as a novel translocation partner of IGH in 9 of 114 cases of gastric, nongastric extranodal, follicular, and nodal diffuse large B-cell lymphoma (DLBCL). Notably, these translocations involving IGHS mu were detected in follicular lymphomas and exclusively in germinal center B cell-like (GCB)-DLBCLs. CD44 is notexpressed in reactive GC B cells. The IGHS mu/CD44 translocations substitute S mu for the CD44 promoter and remove exon 1 of CD44, resulting in the overexpression of I mu-CD44 hybrid mRNA transcripts activated from derivative 11 that encode a new CD44 variant lacking the leader peptide and with a unique C-terminus (CD44 Delta Ex1). When overexpressed in vitro in the CD44(-) GCB-DLBCL cell line BJAB, CD44 Delta Ex1-green fluorescent protein localized to the cytoplasm and nucleus, whereas CD44s-green fluorescent protein (standard form) localized to the plasma membrane. The ectopic expression of CD44 Delta Ex1 in BJAB cells enhanced their proliferation rate and clonogenic ability, indicating a possible pathogenic role of the translocation. (Blood. 2010;115:2458-2461)
著者Hu XT, Chen YW, Liang ACT, Au WY, Wong KY, Wan TSK, Wong MLY, Shen LJ, Chan KK, Guo TH, Chu KM, Tao Q, Chim CS, Loong F, Choi WWL, Lu LW, So CC, Chan LC, Kwong YL, Liang RHS, Srivastava G
期刊名稱Blood
出版年份2010
月份3
日期25
卷號115
期次12
出版社AMER SOC HEMATOLOGY
頁次2458 - 2461
國際標準期刊號0006-4971
電子國際標準期刊號1528-0020
語言英式英語
Web of Science 學科類別Hematology; HEMATOLOGY

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