Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells
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AbstractThe role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone 1, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth and induce caspase-dependent apoptosis concentration-dependently, with dihydrotanshinone being the most potent. All four tanshinones were found to induce ROS generation, but only dihydrotanshinone can induce activation of p38 MAPK. The p38 MAPK activation by dihydrotanshinone was inhibited by N-acetyl cysteine pretreatment. It is thus concluded that ROS-mediated p38 MAPK activation plays a vital role in dihydrotanshinone-induced apoptosis in HepG2 cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListLee WYW, Liu KWK, Yeung JHK
Journal nameCancer Letters
Year2009
Month11
Day18
Volume Number285
Issue Number1
PublisherELSEVIER IRELAND LTD
Pages46 - 57
ISSN0304-3835
eISSN1872-7980
LanguagesEnglish-United Kingdom
KeywordsApoptosis; Caspase; p38 MAPK; Reactive oxygen species; Tanshinones
Web of Science Subject CategoriesOncology; ONCOLOGY