Bone Protection Effects of A Novel Chinese Herbal Formula, Taikong Yangxin Prescription, in Hindlimb Unloaded Rats against Bone Deterioration
Publication in refereed journal


摘要Objective: To investigate the protective effects of a Chinese herbal formula, Taikong Yangxin Prescription (TKYXP) against bone deterioration in a hindlimb unloaded (tail-suspension) rat model. Methods: Thirty-two male Sprague-Dawley rats were divided into 4 groups: tail-suspension group fed with 2.5 of TKYXP extract (high dose), tail-suspension group fed with 1.25 (low dose), tail-suspended group treated with water placebo (placebo control group) and non tail-suspended group. The effects of TKYXP on bone were assessed using peripheral quantitative computed tomography (pQCT), micro-computerized tomography (micro-CT) and three-point bending biomechanical test on the femur in vivo. Results: TKYXP had a significant protective effect against bone loss induced by tail-suspension on day 28, as shown in the reduction in bone mineral density (BMD) loss, preservation of bone micro-architecture and biomechanical strength. The administration ofhigh dose TKYXP could significantly reduce the total BMD loss by 4.8% and 8.0% at the femur and tibia regions, respectively, compared with the placebo control group (P<0.01) on day 28. Its bone protective effect on the femur was further substantiated by the increases of the trabecular BMD (by 6.6%), bone volume fraction (by 20.9%), trabecular number (by 9.5%) and thickness (by 11.9%) as compared with the placebo control group. Conclusion: TKYXP may protect the bone under weightless influence from gradual structural deterioration in the tail-suspension model.
著者Ko CH, Siu WS, Chan CL, Koon CM, Fung KP, Li YZ, Li YH, Leung PC
期刊名稱Chinese Journal of Integrative Medicine
出版社Springer Verlag (Germany)
頁次759 - 764
關鍵詞Chinese herbal medicine; micro-computerized tomography; osteoporosis peripheral quantitative computed tomography; tail-suspension rat model
Web of Science 學科類別Integrative & Complementary Medicine

上次更新時間 2021-15-09 於 04:28