High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections
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AbstractA prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 +/- 1.47; day 3-4, 7.28 +/- 1.41; day 5-8, 6.66 +/- 1.87 log10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log(10) copies/mL increase, 95% confidence interval, 1.03-1.90; P = .034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.
All Author(s) ListLee N, Chan MCW, Lui GCY, Li R, Wong RYK, Yung IMH, Cheung CSK, Chan ECY, Hui DSC, Chan PKS
Journal nameJournal of Infectious Diseases
Detailed descriptionDOI: 10.1093/infdis/jiv248.
Year2015
Month10
Day15
Volume Number212
Issue Number8
PublisherUniversity of Chicago Press / Oxford University Press (OUP): Policy B - Oxford Open Option C
Pages1237 - 1240
ISSN0022-1899
eISSN1537-6613
LanguagesEnglish-United Kingdom
Keywordsrespiratory failure; RSV; viral load
Web of Science Subject CategoriesImmunology; Infectious Diseases; Microbiology

Last updated on 2021-12-05 at 04:39