In Vitro Adsorption of Gentamicin and Netilmicin by Polyacrylonitrile and Polyamide Hemofiltration Filters
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AbstractAdsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmicin were adsorbed to polyacrylonitrile filters in vitro. Adsorption by polyacrylonitrile filters was rapid and irreversible and could be increased by repeated dosing. Adsorption by polyamide filters was substantially less.
All Author(s) ListLam PKN, Tian Q, Ip M, Gomersall CD
Journal nameAntimicrobial Agents and Chemotherapy
Detailed descriptionTo ORKTS: Philip K.N. Lam and Qi Tian contributed equally to the paper.
Volume Number54
Issue Number2
PublisherAmerican Society for Microbiology
Pages963 - 965
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMicrobiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2021-20-09 at 00:00