Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies
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香港中文大學研究人員

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摘要The aim of the present study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) for the oral delivery of Zedoary turmeric oil (ZTO), an essential oil extracted from the dry rhizome of Curcuma zedoaria. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification regions. ZTO could serve as a partial oil phase with the aid of the second oil phase to enhance drug loading. Increasing the surfactant concentration reduced the droplet size but increased the emulsification time, while the reverse effect was observed by increasing the co-surfactant concentration. Based on the emulsification time, droplet size and zeta potential after dispersion into aqueous phase, an optimized formulation consisting of ZTO, ethyl oleate, Tween 80, transcutol P (30.8:7.7:40.5:21, w/w) and loaded with 30% drug was prepared. Upon mixing with water, the formulation was rapidly dispersed into fine droplets with a mean size of 68.3 +/- 1.6 nm and xi-potential of -41.2 +/- 1.3 mV. The active components remained stable in the optimized SNEDDS stored at 25 degrees C for at least 12 months. Following oral administration of ZTO-SNEDDS in rats, both AUC and C(max) of germacrone (GM), a representative bioactive marker of ZTO, increased by 1.7-fold and 2.5-fold respectively compared with the unformulated ZTO. (C) 2009 Elsevier B.V. All rights reserved.
著者Zhao Y, Wang CG, Chow AHL, Ren K, Gong T, Zhang ZR, Zheng Y
期刊名稱International Journal of Pharmaceutics
出版年份2010
月份1
日期4
卷號383
期次1-2
出版社Elsevier
頁次170 - 177
國際標準期刊號0378-5173
電子國際標準期刊號1873-3476
語言英式英語
關鍵詞Bioavailability; Essential oil; Formulation; Pseudo-ternary phase diagram; Self-nanoemulsifying; Zedoary turmeric oil
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

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