Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway
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AbstractHerba Epimedii is one of the most commonly used Chinese herbs for treating osteoporosis. In the present study, the flavonoids of Herba Epimedii (HEF) have shown to promote the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. They were noted to enhance the mRNA expression of BMP-2, BMP-4, Runx2, beta-catenin and cyclinD1, all of which are BMP or Wnt-signaling pathway related regulators. The osteogenic effect was inhibited by the introduction of noggin and DKK-1, which is classical inhibitor of BMP and Wnt/beta-catenin signaling, respectively. These results suggest that HEF exerts promoting effect on osteogenic differentiation, which plausibly functions via the BMP and Wnt/beta-catenin signaling pathways. Considering the therapeutic efficiency and economical issues, HEF may be a potential candidate for promoting bone regeneration. On the other hand, osteogenic differentiation of MSCs may also be a promising and attractive tool to apply in bone repair. (C) 2009 Published by Elsevier Ireland Ltd.
All Author(s) ListZhang JF, Li G, Chan CY, Meng CL, Lin MCM, Chen YC, He ML, Leung PC, Kung HF
Journal nameMolecular and Cellular Endocrinology
Volume Number314
Issue Number1
Pages70 - 74
LanguagesEnglish-United Kingdom
KeywordsBMP signaling pathway; Flavonoids of Herb Epidemium; Mesenchymal stem cells; Osteogenic differentiation; Wnt/beta-catenin signaling pathway
Web of Science Subject CategoriesCell Biology; CELL BIOLOGY; Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

Last updated on 2020-12-08 at 02:15