Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts
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AbstractLong-term exposure to drug may alter the neural system associated with affective processing, as evidenced by both clinical observations and behavioral data documenting dysfunctions in emotional experiences and processing in drug addicts. Although many imaging studies examined neural responses to drug or drug-related cues in addicts, there have been few studies explicitly designed to reveal their neural abnormalities in processing non-drug-related natural affective materials. The present study asked abstinent heroin addicts and normal controls to passively view standardized affective pictures of positive, negative, or neutral valence and compared their brain activities with functional MRI. Compared to normal controls, addicts showed reduced activation in right amygdala in response to the affective pictures, consistent with previous reports of blunted subjective experience for affective stimuli in addicts. Furthermore, in two visual cortical areas BA 19 and 37, while the controls showed greater responses to positive pictures than to negative ones replicating literature findings, the addicts showed the opposite pattern. The results reveal a complex pattern of altered processing of non-drug-related affected materials in addicts showing both heightened and blunted neural responses in different brain regions and for different stimulus valence. The present study highlights the importance of brain imaging research on drug addicts' processing of affective stimuli in understanding disruptions in their emotion circuitry. (C) 2009 Elsevier Inc. All rights reserved.
All Author(s) ListWang ZX, Zhang JX, Wu QL, Liu N, Hu XP, Chan RCK, Xiao ZW
Journal nameNeuroImage
Year2010
Month1
Day1
Volume Number49
Issue Number1
PublisherElsevier
Pages971 - 976
ISSN1053-8119
eISSN1095-9572
LanguagesEnglish-United Kingdom
KeywordsAddiction; Affective processing; Amygdala; Emotion; Heroin; Visual cortex
Web of Science Subject CategoriesNeuroimaging; NEUROIMAGING; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Last updated on 2022-16-01 at 00:16